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Keywords: age-related diseases, healthy longevity, inflammation, oxidative stress, oxidative damage Introduction The average life expectancy has increased rapidly over the past decades, with an average of around 71.4 years in 2015 worldwide (World Health Organization, 2018)

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The metabolic effects of selenium are dose-dependent, and increased SELENOP levels, in particular, disrupt insulin signaling, leading to the development of insulin resistance [76, 77]