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Neves SP, de Carvalho NC, da Silva MM, Rodrigues ACBC, Bomfim LM, Dias RB, et al

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This canonical GHRH pathway stimulates somatotroph proliferation, GH mRNA gene transcription, and pulsatile GH secretion from anterior pituitary cells

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This reduction is key for inhibiting the enzymatic activity of 15-lipoxygenase, primarily by converting its non-heme Fe3+ to an inactive Fe2+ state