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10.1016/j.ijbiomac.2016.09.039 26 HaoC

ChenXWuSChenCXieBFangZHuWet al

This shows that the use of unnatural stereochemistry in GSH is unlikely to prevent the substantial first-pass metabolism by GGT in the liver for orally administered GSH, and it is also unlikely to aid in improving its oral bioavailability [31]