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2.1.4.2 Decision-guided selection criteria: a hierarchy of constraints To implement this framework, we propose a hierarchy centered on three primary engineering determinants: Structural complexity and PTM thresholds: cargoes exceeding 3050 kDa, containing complex disulfide networks, or requiring eukaryotic post-translational modifications (PTMs) should pivot away from genetic fusion toward modular or chemical approaches to prevent catastrophic perturbation of the capsid assembly energy landscape

Transcript What is the biggest takeaway for clinicians from the CagriSema data presented at the 2026 ADA Scientific Sessions

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