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Although this might be seen as a positive for increasing cysteine and glutathione, in fact it is thought that the excess of cystathionine is overall negative and could flood and impair the other pathways below, or specifically increase ammonia

At higher field strengths (3 tesla, T), non-edited approaches have also been applied, relying on peak fitting with prior knowledge of individual metabolite spectra to extract the signal attributable to GSH, using quantification tools such as LCModel (Provencher, 2001)

Furthermore, MFN2 upregulation in CD8 T cells increases the efficacy of immunotherapy by elevating mitochondria-ER contact, which has been confirmed in anti-tumor therapy (118)

In addition, it is a celebrated antioxidant, and is thought to help in cancer prevention, heart disease, and oxidative stress

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