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& Turek, P

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The most commonly used combined outcome is the Combined Assessment of Function and Survival (CAFS), which is a combined, nonparametric test assessing change of ALSFRS-R scores at multiple timepoints while accounting for survival, patient drop-out (censorship), or other prespecified time-to-event endpoints, similar to a rank sum model [49, 50]

In one study, subjects who engaged in 2060 minutes of moderate-to-vigorous physical activity 35 days per week experienced a marked improvement in quality of life that was associated with reduced IBS severity

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