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In the nucleus, P21 acts as a potent inhibitor of cellular proliferation, which abolishes the tumor-suppressive role, but this factor promotes tumor growth when in the cytosol of cancer cells (35,36)

Furthermore, anti-inflammatory therapy, as an adjunct, plays a crucial role in facilitating the smooth transition of the wound from the inflammatory phase to the proliferative phase

642 An open-label randomized trial compared the effect of supplementing with 2 mg per day vitamin K1 with placebo in 72 patients with mild or moderate aortic valve calcification and thickening

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[115] Endogenous melatonin production naturally increases during pregnancy, with maternal melatonin levels rising significantly in the third trimester