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However, recent findings suggest that ROS generation is not the primary or initial cause of aging

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Tordjman S, Somogyi E, Coulon N, Kermarrec S, Cohen D, Bronsard G et al (2014) Gene Environment interactions in autism spectrum disorders: role of epigenetic mechanisms

The development of a highly immunosuppressive TME represents a universal barrier across cancer immunotherapies, limiting durable antitumor immune responses