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Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Genetics 143:973982 Glazebrook J, Zook M, Merrit F, Kagan I, Rogers EE, Crute IR, Holub EB, Hammerschmidt R, Ausubel FM (1997) Phytoalexin-deficient mutants of Arabidopsis reveal that PAD4 encodes a regulatory factor and that four PAD genes contribute to downy mildew resistance

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Upon ingestion, caffeine readily crosses the blood-brain barrier and blocks adenosine receptors , an effect responsible for many of its pharmacologic actions

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