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ALS ALS is a fatal and rapidly progressive neurodegenerative disorder that primarily affects motor neurons in the brain and spinal cord, leading to muscle weakness, atrophy, and ultimately paralysis

Prev Med , 2019, 124: 11-16

Multiple Sclerosis and Related Disorders 1(48):102696 Evonuk KS, Wang S, Mattie J, Cracchiolo CJ, Mager R, Fereni , Sprague E, Carrier B, Schofield K, Martinez E, Stewart Z, Petrosino T, Johnson GA, Yusuf I, Plaisted W, Naiman Z, Delp T, Carter L, Marui S (2023) Brutons tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

Its main role is to shield cellular macromolecules from endogenous and exogenous reactive oxygen species (ROS) and nitrogen ones

A once-daily oral tablet taken at any time of day, with or without food, represents the kind of simplicity that primary care physicians can prescribe and patients can sustain over years of chronic disease management