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About the study In the current study, researchers investigate how alterations in TrkB signaling in iSPNs and changes in the metabolism of glutathione could impact dopamine levels, progressive neuronal degeneration, and the onset of motor dysfunction in Huntingtons disease

Stay Hydrated and Eat a Balanced Diet: Drinking plenty of water throughout the day keeps your skin plump and healthy, which can lessen the sunken look under the eyes

Conclusions We provide initial evidence from in vitro and in vivo models indicating that n-3 polyunsaturated fatty acid (PUFA) supplementation could help reduce toxicity

Glutathione (GSH) is synthesized in the cytoplasm in virtually all cells from its constituent amino acids by two sequential ATP-requiring enzyme-catalyzed reactions (see figure below) [1]

Briefly, separation was carried out using a nano-ACQUITY Ultra Performance LC Chromatography System (Waters Corporation, Milford, MA, USA) with a nano-Acquity UPLC BEH130 C18 RP column and an enrichment Symmetry C18 RP column