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R 3 and R 4 are independently selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, and C1-C12 substituted alkynyl, or optionally R 3 and R 4 together are bonded to form a fused bicyclic ring system or a spirocyclic ring system

These are typically screened for, but are very important for the development of infants' brains

However, this has not been demonstrated in a controlled human trial, and any effect would be additive to, not antagonistic of, evolocumab

doi: 10.1146/annurev-animal-020518-115239 142 JabariASadighi GilaniMAKorujiMGholamiKMohsenzadehMRastegarTet al