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We underscore the involvement of T-bet in the pathogenesis of systemic diseases, including autoimmune disorders, infectious diseases, allergic conditions, endocrine disorders, psychiatric illnesses, and chromosomal abnormalities

Finally, nine of the 44 ferroptosis-related genes were not differentially expressed in any of the analyzed datasets (Supplementary Table 1)

Hypoxia, inflammatory cytokines, elevated oxidative stress, nutritional restriction, and downregulation of SLC7A11 all impede the Na-independent antiporter System Xc in cancer patients, System Xc, which imports a cystine molecule inside the cell and expels glutamic acid from the cell in an ATP-dependent manner [16, 17]

This binding acts as a master switch, upregulating the expression of over 200 cytoprotective genes