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Arimoclomol: a potential therapy under development for ALS

Ikuta, N., Sugiyama, H., Shimosegawa, H., Nakane, R., Ishida, Y., Uekaji, Y., Nakata, D., Pallauf, K., Rimbach, G., Terao, K., & Matsugo, S

This complex covers the pathway more broadly three amino acid precursors (NAC as cysteine source, glycine, glutamine), the cofactor ALA, the polyphenol quercetin, and Vitamin C

While both amino acid replacements have side chains that are polar as opposed to the original glycine, aspartic acid also introduces a negative charge to the surrounding, as well as being larger than serine