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In this study, SFN treatment mitigated the proteinuria and fibrosis seen in the diabetic mice, and also attenuated the kidney levels of profibrotic mediators (TGF- and connective tissue growth factor), inflammatory mediators [plasminogen activator inhibitor -1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1)], and indicators of oxidation (3-nitrotyrosine and 4-hydroxy-2-noneal) [104]

10.1523/JNEUROSCI.23-08-03394.2003 J

Girldez-Prez, R

W.FitzgeraldG

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