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Calorie restriction modulates age-dependent changes in the retinas of Brown Norway rats

Under hypoxia, the stabilized HIF-1 is translocated into the nucleus and dimerizes with HIF-1 and, in turn, binds to a core hypoxia response element in a wide array of genes involved in a diversity of biological processes and directly transactivates glycolytic enzyme genes

[1] A significant increase in resting levels of blood nitrate/nitrite was noted for subjects receiving GPLC compared to placebo (in a double blind design)