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Description

Such observations were made by Trecroci et al

& Dalgarno, L

CX: Conceptualization, Resources, Writing review and editing, Writing original draft

Electrons derived from oxidation of pyruvate mediated by pyruvate dehydrogenase (PDH) and fatty acid oxidation are transferred via NADH to Complex I (FMN-dependent NADH-ubiquinone oxidoreductase), while electrons from succinate in the Krebs cycle, amino acid metabolism, and fatty acid oxidation are transferred to Complex II (FAD-dependent succinate-ubiquinone oxidoreductase) via FADH2

These compounds increase cell permeability and inhibit the activity of selected membrane enzymes/transport proteins, but they can also induce COX-2 expression in macrophages (87)