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However, injections of 55 or 75 mg/kg/day of EGCG induced hepatotoxicity in mice, accompanied by inhibition of hepatic antioxidant enzymes and increased nuclear distribution of Nrf2 (231)

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The expression level of selenoprotein ( selenoprotein M and selenoprotein W-like ) in this study increased significantly from stage AB to stage C and then decline gradually from stage C to stage E, indicating that the alleviation effect of selenoprotein on oxidative stress was the highest in the C stage and the lowest in the E stage

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