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In a forced swimming test, a reduction of the immobility time in bpc 157 (10 microg, 10 ng x kg(-1) i.p.) treated rats corresponds to the activity of the 15 mg or 40 mg (i.p.) of conventional antidepressants, imipramine or nialamide, respectively, given according to the original porsolts protocol

This result agrees with studies exposing rodents to comparable altitudes and reporting elevated MDA levels, confirming that hypoxia elicits oxidative tissue damage 42,43

Six cysteine residues that are in general associated with the antimicrobial activity of the peptide are conserved between the equine, porcine and bovine primary structure

doi: 10.3389/falgy.2022.1007602

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