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Additionally, hypoxia adipocytes can activate the c-Jun N-terminal kinase (JNK) and NF-B pathways, resulting in the synthesis and secretion of pro-inflammatory factors such as IL-6, TNF-, IL-1, IL-12, and IFN-, which induce a SLCI state in adipose tissue (131, 132)

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[DOI] [PubMed] [Google Scholar] 166.Travaini M.L., Sosa G.M., Ceccarelli E.A., Walter H., Cantrell C.L., Carrillo N.J., Dayan F.E., Meepagala K.M., Duke S.O