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TRIM16 deficiency significantly exacerbates cardiomyocyte hypertrophy, while overexpression of TRIM16 inhibits cardiac hypertrophy, suggesting that a TRIM16 inhibitor could be a novel inhibitor of pathological heart hypertrophy and heart failure (Liu J

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The pivotal early-efficacy readout in obesity came from a randomized, double-blind, placebo-controlled, dose-finding Phase 2 trial published in The Lancet Diabetes & Endocrinology (le Roux and colleagues), conducted across 43 centers in 12 countries and registered as NCT04667377

Squalane is a hydrating molecule derived from both plant, human and animal fats

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