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As this complexity continues to unfold, one concept is rapidly gaining traction across disciplinesthat metabolism is not simply the backdrop to development, but a central signaling language through which neurobiological identity is formed and altered

[Google Scholar] | [Crossref] Luo T, Park Y, Sun X, Liu C, Hu B

[58] Digoxin, HSP90 inhibitor 17-DMAG (alvespimycin), and navitoclax, among other senolytic agents, have been shown to significantly decrease atherosclerotic lesion formation and plaque burden in ApoE -/- mice of atherosclerosis

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Further translational research is needed to determine to which degree peripheral markers reflect central mechanisms in order to establish clinically useful peripheral biomarkers