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Each abundance is normalized to the corresponding time-matched vehicle-treated control

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This generates concerns about the long-term effects of exposure

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The impact of this assumption could vary depending on the cause of death assessed, and could, in the case of ischemic heart disease for example, be limited due to the shorter induction period of this condition.28,29 With regard to relative risk, we should point out that the risks applied in the estimation of AM, except for lung cancer, derive mainly from studies conducted in non-European countries where the characteristics of the population, and therefore their exposure to ETS, could be different