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Urine klotho is lower in critically ill patients with versus without acute kidney injury and associates with major adverse kidney events

Thus, CHAC1s role in inducing ER stress and ferroptosis highlights its potential as a therapeutic target to increase the efficacy of DTX in treating castration-resistant prostate cancer ( In vivo experiments confirmed that knocking down miR-432-5p in CAFs enhanced CHAC1 expression, increased ferroptosis, and improved the efficacy of docetaxel in reducing tumor growth

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doi: 10.1016/j.psj.2024.103482 72 WangSZhangBChangXZhaoHZhangHZhaoTet al

4.3 Biomarker-driven optimization Biomarkers such as AMH, oxidative stress markers, and follicular fluid composition provide a means for real-time monitoring of interventions