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It is unknown whether PE N -chloramines occur in vivo and their physiological role and biological activity are still under investigation, since, due to the inherent instability of N -chloramines, their detection is challenging

Insufficient GSH, the only antioxidant in the hypothalamus, may cause ferroptosis in some neurons, leading to further metabolic disorders

Yunes, R

This indicates that the likelihood of precipitating withdrawal is low (precipitated withdrawal is most likely with lower doses of buprenorphine, when buprenorphine first starts knocking agonists off the opioid receptors)