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Constructing miR-135b-3p mimics and inhibitor vectors in myocardial cells revealed that miR-135b-3p directly targets the ferroptosis-related gene GPX4, increasing intracellular iron levels, reducing antioxidant capacity, and participating in I/R-induced ferroptosis [112]

Neuromodulation, especially dorsal root ganglion stimulation, is considered for severe, chronic, highly localized pain that has not responded to medication, topical treatment, blocks, or rehabilitation

While the gut microbiota has been shown to modulate homeostatic and hedonic feeding pathways in adult studies 40,45,46,47,49 , and, separately, to influence the hosts developing neuro-immune-endocrine pathways 57,59,82 , the mechanisms through which the early-life microbiota affects the homeostatic and hedonic feeding systems remain to be fully elucidated

Hepatology 59 , 23832396 (2014)

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