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Biomedicines 10 (12), 3088

Arginine methylation is an abundant PTM in which a methyl group is added to the arginine residues of a protein to modify recognition by binding partners or to modulate their biological activity 95,96

It is projected that the incidence of PD will increase two-fold to reach 12.9 million cases by the year 2040, thereby establishing it as an escalating concern within the healthcare domain 2

For platinum-resistant patients: when azacitidine was combined with valproic acid and carboplatin, 18.8% of patients achieved stable disease or minor response, but the study was terminated early due to a high rate of grade 3 or higher adverse events [170]