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TPCA-1, a dual inhibitor targeting IKK-2 and STAT3, effectively blocked this synergistic IL-6 increase, inhibited STAT3 activation, and reduced C/EBP levels

Role of mTORC1 in the sensing of defective mitochondria mTORC1 contributes to the detection of defective mitochondria not only by regulating organelle dynamics and isolating damaged organelles through fission but also by modulating communication with the nucleus via retrograde signaling, particularly when the mitochondrial genome needs to be repaired (Fig

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