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This inhibitor substantially decreased the number of cells in adherent and spheroid cultures as well, nevertheless it has increased their tumorigenic potential as determined by higher frequency of tumor-initiating cells in vivo

While some evidence for this effect is for acute high-dose exposure (Yadla 2013

10.1016/S0149-2918(03)80130-3 11

The activity of NADPH oxidase (Nicotinamide adenine dinucleotide phosphate oxidase, NOX) is upregulated in the aorta, kidney, and adipose tissues in high fat diet-fed rats, leading to excessive production of superoxide ions a major oxygen free radical (129)

Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions