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Growth/differentiation factor-15 (GDF-15) Another potential therapeutic pathway for obesity pharmacotherapies is through the stress-induced cytokine GDF-15, which is expressed in multiple cell types including cardiomyocytes, adipocytes and macrophages [98]

This aggregation is often irreversible

In an elegant study comparing genetically identical mice housed in different rooms, the authors discovered that one colony had a colonic mucus layer that was impenetrable by bacteria, while the other colony had the opposite

Type 1 diabetes is primarily caused by destruction of insulin-producing pancreatic beta cells by autoimmune disease or rarely other causes such as trauma