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It has been suggested that metformin displays potential beneficial effects by reducing several cardiovascular dysfunction risk factors, such as body mass index (BMI) (MD: 0.53 kg/m 2 , 95% CI 0.95, 0.12), insulin-resistance (HOMA-IR) (MD:0.50, 95% CI 0.91, 0.09), triglyceride (MD: 0.11 mmol/L, 95% CI 0.20, 0.02), plasma plasminogen activator inhibitor-1 (Ruth, Day et al.) (MD: 4.99 ng/mL, 95% CI 6.78, 3.21) (Li and Li, 2023), carotid intima-media thickness (CIMT), and flow-mediated dilation (FMD) (Wang et al., 2024) in PCOS patients

A comprehensive review of free radicals, oxidative stress, and antioxidants: overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds

FEBS Letters, 368: 225229

Matzinger et al., 2017)

doi: 10.1016/S0021-9258(18)38248-6 81 RoseS.MelnykS.PavlivO.BaiS.NickT