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The models were validated in both internal and external cohorts

New strategies, such as pharmacological inhibitors, metabolic interventions, and RNA sequencing for biomarker detection, are enhancing our comprehension of how autophagy aids cancer stem cell persistence and resistance to therapy

Moreover, the same group showed that HIF-1 stabilization by dimethyloxalylglycine (DMOG) modulates the macrophage phenotype by restoring M1 metabolism (244)