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Consistent with these findings, TRPV4 overexpression in human lung adenocarcinoma A549 cells elevated intracellular calcium concentrations and induced ERS (Yoo et al., 2020)

Ceruloplasmin, an abundant acute phase protein in plasma, acts as an important antioxidant, which has been shown to directly bind and inhibit MPO [322], interfere with HOCl production [323] and thus, for instance, prevent HOCl-mediated degradation of the 1 -antiproteinase and other proteins [30]

This suggests that T cells expressing the disease associated TCRs have undergone clonal expansion in the inflamed tissues

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