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cerevisiae strains C3G1-C3G10 and DHQC3G1DHQC3G10 (Supplementary Table 5) were restreaked on SC-ULH plates (1.47 g l 1 Synthetic Complete (Kaiser) Drop Out: Leu, His, Ura, 6.7 g l 1 yeast nitrogen base (without amino acids), 20 g l 1 d-(+)-glucose, 16 g l 1 agar) or SC-U plates (SC-ULH, 380 mg l 1 leucine, 76 mg l 1 histidine), respectively

Para el investigador que evala 5-Amino-1MQ, esta diferencia farmacocintica es central al disear protocolos: la permeabilidad de membrana permite ensayos en cultivo celular sin agentes de transfeccin y modelos de dosificacin oral en roedores, lo que ampla las posibilidades experimentales frente a herramientas peptdicas del mismo eje metablico