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After confirming the position of the needle, a steroid-anaesthetic mix is injected into the piriformis muscle

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The pivotal SURMOUNT-1 trial showed 15 to 22 percent mean body weight loss over 72 weeks at therapeutic doses

The STEP 1 trial, published in the New England Journal of Medicine , demonstrated that participants receiving semaglutide 2.4 mg weekly lost an average of 14.9 percent of their body weight over 68 weeks, compared to 2.4 percent with placebo (Wilding et al., 2021)