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6 Emerging flavonoid subclasses with translational promise While quercetin, apigenin, and kaempferol dominate historical discussion, several less-covered subclasses now show compelling anticancer signals together with formulation paths that address exposure limits

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EGFR activation leads to induction of MAPK signaling (via p38, ERK1/2) and the activation of c-Fos (Naglik et al., 2019), ultimately triggering the production of inflammatory mediators such as G-CSF and GM-CSF (Nikou et al., 2022), and the activation of the NLRP3 inflammasome leads to the release of IL-1 (Rogiers et al., 2019)

The cells were then counterstained with DAPI (AR1176, Abbkin) and imaged with fluorescence microscopy