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Arginine might also affect blood sugar control, it can enhance insulin release and sensitivity, so in patients on antidiabetic medications, combining arginine could increase the risk of hypoglycemia and necessitates close glucose monitoring

doi: 10.1016/j.exer.2020.107961 320 AshokASinghNChaudharySBellamkondaVKritikosAEWiseASet al

Intravenous skin-lightening evidence is particularly weak

An open trial that included 32 women with PCOS found a multi-nutrient supplement providing 400 mcg (680 mcg DFE) 5-MTHF daily for three months decreased homocysteine levels compared with no treatment