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it cannot establish superiority, because differences in population, comparator, endpoint, dose, and trial length confound any direct read

Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2

Appetite & satiety control Investigated for how it mimics the satiety hormone amylin to curb hunger and lower food intake in research settings