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Interestingly, a recent study showed that oral supplementation of NR altered the intestinal microbial composition in rats and mice but not humans 63 , highlighting the need for further studies on this matter to assess the impact of NAD + metabolism modulation by the microbiome on health outcomes

Federici M, Zucaro L, Porzio O, Massoud R, Borboni P, Lauro D, Sesti G

Brief report: weight gain in persons with HIV switched from Efavirenz-Based to integrase strand transfer Inhibitor-Based regimens

In addition to the lean and ob/ob mice, the study included 3-KO mice and WT controls obtained from genetically verified breeding colonies