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ROS are directly or indirectly associated with cytokine storm induction in SARS-CoV-2 infection, and ROS can activate NF-B and NLRP3 inflammasomes, thereby leading to the production of inflammatory cytokines and the development of acute respiratory distress syndrome and multiple organ dysfunction 62,63,64

The sealed pen prevents copper oxidation that occurs when vials are repeatedly opened, maintaining the bioactive Cu(II) form

Local pain and tenderness at the injection site, urticaria and angioedema may occur

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