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These metabolic benefits translate into whole-body effects: for example, in diet-induced obesity models, MOTS-c administration prevented excessive weight gain and insulin resistance when mice were fed a high-fat diet, without affecting weight in lean diets

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Discussion Cellular senescence has been implicated in various biological processes including cancer and tissue repair

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To further clarify the mechanism of DIS, TGF-1 was used to induce a renal fibrosis model in vitro

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The lysine residue's positive charge facilitates interaction with glycosaminoglycans and negatively charged phospholipids in cellular membranes, enhancing uptake efficiency

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