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Cuproptosis is associated with major cardiac and vascular diseases, including myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, sepsis-induced cardiac injury, hypertrophic cardiomyopathy, atherosclerotic cardiovascular disease, heart failure, aortic aneurysm, and hypertension

One of the ways in which ROS promotes cell apoptosis is by exacerbating the conformational changes and translocation of the Bcl-2-associated X protein (Bax)