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Antioxidants (basel) 8:384

[DOI] [PubMed] [Google Scholar] 75.Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, Mavroukakis SA, White DE, Wunderlich JR, Canevari S, Rogers-Freezer L, et al

Psychopharmacology (Berl.) 198 , 7791 (2008)

Vigorous shaking introduces air bubbles and mechanical shear that disrupt peptide structure, visible as foam formation that signals protein denaturation in progress

A narrow therapeutic window for these effects, however, has led to concerted efforts to understand the molecular mechanisms of lithium action in the central nervous system (CNS), in order to develop more selective treatments that harness its neuroprotective potential whilst limiting its toxic side-effects