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Morita M, Gravel SP, Chnard V, Sikstrm K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N (2013) mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

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Without these structural reforms, the field risks mistaking molecular promise for therapeutic progress and stalling the development of interventions that could meaningfully alter the trajectory of neurodegenerative disease