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Weighing antitumor immunity against life-threatening myocarditis from immune-checkpoint inhibitors

FIGURE 8 FIGURE 9 Clustering analysis of 107 DEMs based on the Z-score values identified 41 metabolites with downregulated expression between the RY-A and 2VO groups, including L-fucose (VIP = 2.85, p = 0.000047), trolox (VIP = 2.84, p = 0.00092), and 3-(imidazol-4-yl) propionic acid (VIP = 2.81, p = 0.0071), and the upregulation of 66 metabolites, such as 12-oxoETE (VIP = 2.73, p = 0.012), GSH (VIP = 2.65, p = 0.023), and adrenic acid (AA, VIP = 1.96, p = 0.012) (Figures 9D, E)

Prevalence and functional consequence of PHOX2B mutations in neuroblastoma

& Al-Qazzan, M

Adverse events following tribendimidine treatment include vertigo, headache, nausea, fatigue, anxiety, and, occasionally, vomiting (260, 262, 272, 275)