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This peptide plays a crucial role in regulating wound healing and tissue remodelling processes

In some embodiments, the otic formulation comprises between about 0.0001% to about 5% by weight of the weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

iPSC-derived brain endothelium exhibits stable, long-term barrier function in perfused hydrogel scaffolds

Changes in the BBB associated with Alzheimer's disease primarily include endothelial abnormalities such as reactive gliosis, mitochondrial damage, alterations in the extracellular matrix, disrupted tight junctions, and both molecular and functional changes in astrocytes

This effect is crucial for maintaining endothelial integrity and responding to ischemic or inflammatory insults in experimental models