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PARPs, on the other hand, respond to DNA damage by using NAD + to generate ADP-ribose polymers, which are essential for DNA repair and maintaining genome stability

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No statistically significant differences in durable clinical remission or CS-free clinical remission at Week 52 vs placebo 15 ENTYVIO IV ENTYVIO SC Placebo CS=corticosteroid

The bone effects of amylin analogues also deserve investigation, as these drugs not only bind the amylin receptors AMY1R, AMY2R, and AMY3R, but also the calcitonin receptor, raising the possibility of direct effects on bone metabolism [10]