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Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat

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Studies in animal models of ischemic stroke showed that lactate, either endogenously produced during hypoxia or applied exogenously at reoxygenation, supports energy metabolism and functional recovery in neurons 23,24,25,26 , and that direct intracerebroventricular or intravenous injection of lactate led to a decrease in infarct volume and an improvement in neurological outcome 26,27