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It is best suited for patients experiencing energy depletion, poor exercise tolerance, or metabolic resistance that does not improve with lifestyle changes alone

After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

Researchers proceeding with this stack should do so with conservative dosing, structured monitoring, and clear stopping criteria if adverse events emerge

In a pool of Study 1 and 2, hair loss was reported more frequently in female than male patients in the ZEPBOUND (7.1% female versus 0.5% male) and placebo (1.3% female versus 0% male) treatment groups

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