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The Office of Science and Technology, with the Office of Management and Budget and the National Security Council, as well as representatives from each agency, examined various options to increase the probability of success and reduce the risk to data continuity

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Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

Beyond 28 days, oxidation of the histidine residue progresses to the point where biological potency drops below therapeutic levels, even under ideal storage conditions

While vitamin B12 can be taken orally, many patients will benefit from injections as they allow the vitamin to be absorbed in a higher proportion than other forms of supplementation